Most Bioavailable Form of Curcumin
The best form of curcumin bioavailability
Turmeric has been used by physicians for a long time. It contains curcumin, but the bioavailability of curcumin is often a concern for physicians. Bioavailability is related to the degree and rate of the drug reaching the site of action after entering the body, and is crucial for the efficacy of curcumin.
Investigate the reasons for its poor bioavailability, and first of all, its chemical structure. The chemical structure of curcumin causes its low solubility in the aqueous phase, which is an obstacle to oral absorption. The absorption environment of the intestine is mostly water-based, and curcumin is difficult to dissolve, so it is difficult for the intestinal wall cells to uptake, which in turn affects the blood entry and systemic distribution.
Furthermore, curcumin is easily metabolized and decomposed in the body. Once taken orally, curcumin enters the gastrointestinal tract, and is affected by gastric acid, digestive enzymes and intestinal flora, resulting in a variable structure and reduced activity. And when metabolized by the liver, curcumin easily binds to the reaction to generate polar metabolites, which are quickly excreted from the body, resulting in less retention in the body.
As for the best form of bioavailability, one is nano-preparation. Nanotechnology can make curcumin into nanoparticles, nano-micelles, etc. The nanoscale particle size greatly increases its specific surface area and improves solubility. Nanoparticles can simulate the structure of biological membranes and enter cells by endocytosis to improve absorption efficiency. If curcumin is loaded with nano-micelles, it can be evenly dispersed, stable in an aqueous environment, and better absorbed in the intestine.
The second is a liposome preparation. The liposome uses a phospholipid bilayer as a membrane material, which is biocompatible and targeted. Curcumin is encapsulated in the aqueous phase of the liposome or embedded in the phospholipid layer, which can avoid damage to the gastrointestinal tract. The liposome fuses with the cell membrane or is engulfed, promoting curcumin into the cell and improving bioavailability.
The third is in combination with piperine. Piperine is a component of pepper, which can inhibit drug metabolism enzymes in the intestines and liver, and slow down curcumin metabolism. The combination of the two prolongs the residence time of curcumin in the body, and the bioavailability increases.
In summary, nano-preparations, liposomal preparations, and combined use with piperine are all good ways to improve the bioavailability of curcumin. When taking medicine, doctors can choose it according to the situation to achieve the best efficacy of curcumin.
