Turmeric Ibuprofen Interactions
Interaction between turmeric and ibuprofen
Turmeric, which is spicy, bitter, warm, returns to the spleen and liver meridians, has the effect of breaking blood and promoting qi, passing through the meridians and relieving pain. It is often used for tingling in the chest and flank, amenorrhea,
, rheumatism, shoulder and arm pain, swelling and pain. Ibuprofen, a common non-steroidal anti-inflammatory drug, is mostly used to relieve mild to moderate pain, such as headache, joint pain, toothache, etc., and is also used for fever caused by the common cold or influenza. If the two are used improperly, there may be a risk of interaction.
In terms of pharmacological mechanism, turmeric contains active ingredients such as curcumin, which have anti-inflammatory and antioxid Ibuprofen reduces prostaglandin synthesis by inhibiting the activity of cyclooxygenase (COX), thereby reducing inflammation and pain sensation. Although both have anti-inflammatory effects, the target and route of action may be different. If used at the same time, or the anti-inflammatory effect is superimposed, although it may gain in relieving some inflammatory symptoms, it may also increase the chance of adverse reactions.
In terms of pharmacokinetics, turmeric may affect the metabolism of ibuprofen in the body. Turmeric may induce or inhibit enzymes in the liver involved in drug metabolism, such as cytochrome P450 enzyme system. If the enzyme system is induced, the metabolism of ibuprofen is accelerated, the blood concentration is reduced, and the curative effect is weakened; if the enzyme system is inhibited, the metabolism of ibuprofen is slowed down, the blood concentration is increased, and the risk of adverse reactions is increased, such as gastrointestinal discomfort and liver damage.
In clinical application, if patients need to use turmeric and ibuprofen together, they must consult a professional doctor or pharmacist. The doctor will weigh the pros and cons according to the patient's specific condition, constitution and other factors, and formulate an appropriate medication plan. Patients must not use the combination at will, so as not to damage their health due to drug interaction. During the medication period, they should pay attention to the changes of their own symptoms. If there are any abnormalities, such as severe gastrointestinal reactions, allergic symptoms, etc
