Turmeric Warfarin Interaction
"On the Interaction between Turmeric and Warfarin"
Turmeric, a genus of herbs, has a yellow fragrance and has been used as a medicine for a long time. Warfarin, an anticoagulant commonly used by doctors. The interaction between the two in the human body is quite important in the medical world.
According to the pharmacology, turmeric is rich in curcumin and other ingredients. Curcumin has various pharmacological activities, but it may have an impact on the anticoagulant mechanism of warfarin. Warfarin is metabolized by the liver cytochrome P450 enzyme system, and the components of turmeric may interfere with this metabolic pathway.
In clinical practice, some patients took warfarin to anticoagulant blood, and also took turmeric-related products. After a while, the coagulation index changed abnormally. Cover turmeric enhances the anticoagulant effect of warfarin, which increases the risk of bleeding. In mild cases, skin ecchymosis and gum bleeding; in severe cases, intracranial and digestive tract bleeding, endangering life.
There are also studies showing that the combination of turmeric and warfarin can cause the blood concentration of warfarin to rise. This is because turmeric inhibits the drug metabolism enzymes in the liver, which slows down the metabolism of warfarin and accumulates in the body, and the anticoagulant effect is too strong.
Therefore, when a doctor uses drugs, the patient's medication history must be reviewed carefully If the patient is taking warfarin, turmeric products should be recommended with caution. Patients should not use it without authorization to avoid drug damage. The way of medication is related to life and cannot be ignored.
